HMG-CoA Reductase (HMGCR)

Related Products

HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes. The phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea.

Both in eukaryotes and in archaebacteria the enzyme HMGCR is known to catalyze an early reaction unique to isoprenoid biosynthesis. In humans, the HMG-CoA reductase reaction is rate-limiting for the biosynthesis of cholesterol and therefore constitutes a prime target of drugs that reduce serum cholesterol levels.

HMG-CoA Reductase (HMGCR) 관련 제품 (158)
Antibodies (13)

By Effects:	Inhibitors (136) Degrader (1) Controls (6) Substrate (1)

Cat. No.	상품명	효과	Purity	Chemical Structure

HY-N16439

Phenicin	Inhibitor
Phenicin (Phoenicine), a microbial metabolite, is an irreversible HMG-CoA reductase (HMGCR) inhibitor. Phenicin can be isolated from cultures of Penicillium phoeniceum and Penicillium rubrum. Phenicin specifically inhibits the conversion of HMG-CoA to mevalonate catalyzed by HMGCR, effectively inhibiting cholesterol synthesis.

HY-W414588

Colestolone	Inhibitor
Colestolone is a 15-ketosterol compound and an orally active inhibitor of HMG-CoA reductase. Colestolone can inhibit the activity of cholesteryl ester transfer protein (CETP) in vitro (IC₅₀= 660 μM). Colestolone is a cholesterol-lowering agent, and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia.

HY-W707564

Atorvastatin-d₅-1 sodium
Atorvastatin-d₅-1 sodium is the deuterium labeled Atorvastatin sodium (HY-108257). Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively.

HY-129458

Cerivastatin	Inhibitor
Cerivastatin is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin reduces low-density lipoprotein cholesterol levels. Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.

HY-113725

L 668411	Inhibitor
L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.

HY-119695AS1

Simvastatin acid-d₉ ammonium	Inhibitor
Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

HY-137310

4-Hydroxy atorvastatin hemicalcium
4-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin.

HY-178268

Tenivastatin calcium	Inhibitor
Tenivastatin calcium is a HMG-CoA reductase inhibitor. Tenivastatin calcium can reduce blood lipid level can be used for the research of hyperlipidemia.

HY-N15097

Dihydrocompactin	Inhibitor
Dihydrocompactin, an antifungal metabolite, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMG-CoA reductase) from Penicillium citrinum.

HY-106380

Glenvastatin	Inhibitor
Glenvastatin (HR 780) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Glenvastatin can reduces plasma total cholesterol and phospholipid levels and liver cholesterol contents. Glenvastatin does not increase the contents of cholesterol and total bile acid in the gallbladder bile. Glenvastatin can be used for the research of hyperlipemia

HY-N6712R

Thiolutin (Standard)	Inhibitor
Thromycin (Standard) is the analytical standard of thromycin (Acetopyrrothin) (HY-N6712). Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin (HY-15142A)-induced cardiotoxicity (DOXIC)^{[1][2][3][4][5]}.

HY-137213

Fluvastatin lactone	Control
Fluvastatin lactone, a lactone form of Fluvastatin (HY-14664), induces myotoxicity in human skeletal muscle cells.

HY-176089

Adenosine-5'-O-diphosphoribose phosphate sodium	Inhibitor
Adenosine-5'-O-diphosphoribose phosphate sodium is a structural analog of NADPH (HY-113324). Adenosine-5'-O-diphosphoribose phosphate sodium is an HMG-CoA reductase inhibitor. Adenosine-5'-O-diphosphoribose phosphate sodium inhibits microsomal HMG-CoA reductase with an apparent K_i value of 550 μM at low thiol concentrations.

HY-N7264R

7α-Hydroxycholesterol (Standard)	Inhibitor
7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis.

HY-Z8472

Dihydromevinolin	Inhibitor
Dihydromevinolin is a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Dihydromevinolin is a HMG-CoA reductase inhibitor.

HY-119695AS2

Simvastatin acid-d₃ ammonium	Inhibitor
Simvastatin acid-d₃ (Tenivastatin-d₃) ammonium is deuterium-labeled Simvastatin acid (ammonium) (HY-119695A).

HY-13528R

Clinofibrate (Standard)	Inhibitor
Clinofibrate (Standard) is the analytical standard of Clinofibrate. This product is intended for research and analytical applications. Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor.

HY-100793R

SR12813 (Standard)	Inhibitor
SR12813 (Standard) is the analytical standard of SR12813 (HY-100793). This product is intended for research and analytical applications. SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM. SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR).

HY-16166

Dalvastatin
Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.

HY-180457

GR 92549	Inhibitor
GR 92549 is a potent, orally active, and competitive HMG-CoA reductase inhibitor, can be used as a cholesterol lowering agent.

Name
이메일 *

	Sorry, but the email address you supplied was invalid.

HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR) 관련 제품 (158)

Antibodies (13)

HMG-CoA Reductase (HMGCR) 관련 제품 (158):